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October 1970

Nodular Lymphoid Hyperplasia of the Small Intestine and Sarcoidosis

Arch Intern Med. 1970;126(4):668-672. doi:10.1001/archinte.1970.00310100114016

A remarkable syndrome has been recognized which consists of nodular lymphoid hyperplasia of the small intestine, hypogammaglobulinemia, antibody deficiency, and chronic diarrhea.1-5 We report here the singular association of this syndrome with sarcoidosis. Noncaseating granuloma was found in a lymph node, and mediastinal and pulmonary masses were present which disappeared during γ-globulin therapy. The patient remains in good health after five years of observation.

Patient Summary  The patient is a 36-year-old man who has been well and working full-time. The first suggestion of an abnormal state occurred in January 1964 when he donated blood. His blood was found to be lacking in isohemagglutinins, and he was admitted for study in April. Beginning at age 1 year, the patient had several episodes of otitis media which responded well to antibiotic treatment. He had uncomplicated measles in childhood and scarlet fever and mumps orchitis at age 11 years. He had a