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December 1970

Hyperdynamic Beta-Adrenergic: Circulatory State

Author Affiliations

Oklahoma City; Cleveland

From the Division of Hypertension, Department of Medicine, the University of Oklahoma Medical Center, Oklahoma City (Dr. Frohlich) and the Research Division, Cleveland Clinic (Drs. Dustan and Tarazi).

Arch Intern Med. 1970;126(6):1068-1069. doi:10.1001/archinte.1970.00310120130016

In a recent communication published in the Archives Bourne et al1 reviewed certain published literature concerning intravenous infusions of isoproterenol and related these observations to one of our clinical investigations dealing with patients having "hyperdynamic beta-adrenergic circulatory state".2 The authors concluded that (a) our data in 25 normal volunteer subjects and 27 hypertensive patients concerning isoproterenol-induced cardioacceleration failed to coincide with three cited studies involving five, three, and four subjects, respectively3-5; (b) we failed to answer completely the theoretical questions involved, and (c) our data do not justify therapy of our patients with propranolol hydrochloride.

It is always of great value to question and reevaluate concepts, to confirm or refute observations, and to welcome criticism; however, additional data as an alternative to our published observations were not available. The reader, therefore, is left with a theoretical challenge to real observations. The presentation, therefore, deems our answer mandatory.

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