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December 1970

Recent Results in Cancer Research: Rubidomycin.

Author Affiliations

Washington, DC

Arch Intern Med. 1970;126(6):1079-1080. doi:10.1001/archinte.1970.00310120141031

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This monograph contains a rather complete tabulation of the current data on a new antibiotic with antitumoral activity. This antibiotic known as Rubidomycin (Daunomycin, daunorubicin) was originally extracted from a strain of streptomyces and called Rubidomycin by the French. Almost concurrently the Italians extracted from another strain of streptomyces an identical antibiotic which they called Daunomycin. Daunorubicin occurs as a red, crystalline powder and belongs to the anthracycline group of glycoside antibiotics. Experimentally, the agent has antitumoral activity against a variety of animal sarcomas and carcinomas as well as leukemias and tumors of viral origin. The compound acts through its mitostatic ability which changes chromosome structure and disrupts the metabolism first of DNA and subsequently RNA.

Bernard, Paul, Boiron, Jacquillat, and Maral have divided their monograph into two major sections. The first deals with the preparation, structure, biological activity, mechanism of action, and toxicology of Daunorubicin. The second section

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