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January 1971

Abnormalities of Plasma Volume in Borderline Hypertension

Author Affiliations

Ann Arbor, Mich

From the Department of Internal Medicine, Hypertension Unit, University of Michigan Medical Center, Ann Arbor, Mich. Dr. Reilly is now with the St. Vincent's Hospital, New York.

Arch Intern Med. 1971;127(1):116-119. doi:10.1001/archinte.1971.00310130120021

Patients with borderline hypertension have decreased plasma volume. This is a reproducible finding. Decreased plasma volume is associated with increases of the hematocrit reading. Increased cardiac output and heart rates were observed in borderline hypertension, but this was not associated with the decrease of the plasma volume. However, the decreased plasma volume was correlated with increases of the blood pressure and of the total peripheral resistance. Since the decrease of plasma volume clearly relates to indices of "severity" of borderline hypertension (blood pressure and resistance), measurement of plasma volume may be important for understanding the natural history of the disease and for the assessment of an individual's risks.

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