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February 1971

Lymphosarcoma of the Spleen: Results of Diagnostic Splenectomy in 11 Patients

Author Affiliations


From the Hematology Research Laboratory, Peter Bent Brigham Hospital and Harvard University Medical School, Boston. Dr. Davey is now with the Department of Pathology, Letterman General Hospital, San Francisco.

Arch Intern Med. 1971;127(2):259-265. doi:10.1001/archinte.1971.00310140087011

Diagnosis of lymphosarcoma primarily involving the spleen was established by splenectomy in 11 patients. Duration of splenomegaly varied from two months to six years. In three patients the only finding was splenomegaly while eight had massively enlarged spleens with varying degrees of pancytopenia. The hypersplenic effect was abolished in all patients following splenectomy. Blood pictures compatible with lymphatic leukemia subsequently developed in 6 of 11 patients; the leukemic phase was transitory in two cases and two of the remaining four required chemotherapy. Follow-up time after surgery has ranged from 1 to 16 years with a median of 31/2 years. This experience supports the observations of others that patients with lymphosarcoma primarily involving the spleen tolerate splenectomy well and benefit from this procedure despite development of a leukemic blood picture in some cases.