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March 1971

Environmental Influence on Intrauterine Lung Development

Arch Intern Med. 1971;127(3):421-425. doi:10.1001/archinte.1971.00310150081011

Recent advances in developmental biology suggest that alterations in functional maturation of specific organs may serve as a model to assess adverse effects of environmental factors. Maturation of the mammalian lung depends on integrity of the hypothalamic-pituitary-adrenal axis controlling glucocorticoid production and interference with this system retards or prevents acquisition by the lung of factors essential for extrauterine existence.