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The authors of this monograph, pediatric allergist, dermatologist, and immunologist, propose to present "basic information on immunologic mechanisms and their application to diagnosis and treatment of human disease" as well as "condensing the high points of current literature." Basically, the problem is whether any of these broad topics which include basic immunology, clinical aspects of atopic diseases, autoimmune systemic connective-tissue disorders, transplantation immunology, and disorders with excess or deficiencies with immunoglobulins, can be adequately covered to provide sufficient practical knowledge for any level of interest in a book of less than 100 pages. Many sections are most brief and sketchy. For example, primary acquired agammaglobulinemia, is dispensed with in two sentences! Immunoglobulin E receives only brief comment and serum levels are not mentioned, although they have been done for years. Therapy for severe status asthmaticus is outlined in less than one page, in a manner totally inadequate to make this