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October 1971

Salmonellosis in Patients With Neoplastic Disease: A Review of 100 Episodes at Memorial Cancer Center Over a 13-Year Period

Author Affiliations

New York

From the Department of Medicine (Microbiology Laboratory), Memorial Cancer Center, New York. Dr. Wolfe is now with the Department of State, Office of Medical Services, Washington, DC.

Arch Intern Med. 1971;128(4):546-554. doi:10.1001/archinte.1971.00310220054005

One hundred Salmonella isolations from 95 patients at Memorial Cancer Center over a 13-year period were reviewed. Salmonella typhimurium and Salmonella derby made up 61% of the isolations. Practically all patients had serious underlying disease, and most were under or had undergone recent adrenocorticosteroid treatment, chemotherapy, radiotherapy, or surgery. The predisposition of patients with recent surgery to salmonellosis was reaffirmed. A striking relationship was found between patients with leukemia and lymphoma and S typhimurium septicemia. It is suggested that the hemolytic component in these diseases may predispose to S typhimurium septicemia, and these diseases should perhaps be included with sickle-cell disease, bartonellosis, and malaria in having a specific predisposition to associated salmonellosis. A number of unusual Salmonella infections were noted.

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