This report encompasses a 20-year study of 241 male patients with Graves' disease. All patients received a therapeutic dose of sodium iodide I 131 calculated from the 24-hour thyroid uptake, the effective half-life of the retained 131I tracer dose, and the gland weight. The gland weight was determined by an empirical weight formula from the thyroid scintigram. Forty-five percent of the total patient group and 74% of the Negro patients required multiple doses. Patients who required multiple doses had more severe laboratory abnormalities and lost more weight. These patients also became hypothyroid later and ultimately had a higher incidence of hypothyroidism than patients who received single doses. The mean incidence of hypothyroidism for the entire series was 27.8%. The actual number of millicuries of 131I required to deliver the therapeutic dose had little or no relation to the ultimate therapeutic effect.
Blahd WH, Hays MT. Graves' Disease in the Male: A Review of 241 Cases Treated With an Individually Calculated Dose of Sodium Iodide I 131. Arch Intern Med. 1972;129(1):33–40. doi:10.1001/archinte.1972.00320010037002
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