[Skip to Navigation]
March 1972

Chronic Intravascular Coagulation in Kasabach-Merritt Syndrome: Preferential Accumulation of Fibrinogen 131I in a Giant Hemangioma

Author Affiliations

Zurich, Switzerland

From the Department of Medicine, Kantonsspital, and the Department of Orthopedics, Klinik Balgrist, University of Zurich, Zurich, Switzerland.

Arch Intern Med. 1972;129(3):475-478. doi:10.1001/archinte.1972.00320030095011

"Intravascular coagulation"1-5 has repeatedly been incriminated for the hemorrhagic diathesis associated with giant hemangiomas originally described by Kasabach and Merritt in 1940.6 The reversal of the abnormalities by anticoagulants1 and survival studies with labeled fibrinogen5,8 have firmly established its pathogenetic role.

In the present report a massive preferential accumulation of the radioactivity of fibrinogen tagged with iodine 131 in the region of a giant hemangioma is documented, suggesting a localized rather than a generalized intravascular consumption of fibrinogen in this disorder.