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April 1972

Glucose Intolerance in Wilson's Disease: Normalization After Treatment With Penicillamine

Author Affiliations

Aarhus, Denmark

From the First and Second University Clinics of Internal Medicine, Kommunehospitalet, Aarhus, Denmark.

Arch Intern Med. 1972;129(4):587-590. doi:10.1001/archinte.1972.00320040063007

Moderate glucose intolerance with concomitant hyperresponse of insulin production and absence of the normal suppression of growth hormone level in blood was found in two siblings with Wilson's disease. The abnormalities disappeared after one year's treatment with penicillamine at the time when liver biopsy showed normalization of the liver structure.

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