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April 1972

Acute Plasmodium falciparum Malaria: Vital Capacity, Blood Gases, and Coagulation

Author Affiliations

USN; USNR; USNR; USNR, Da Nang, Republic of Vietnam

From the Bureau of Medicine and Surgery, Navy Department, Research Task M4305.053042A. The work described in this manuscript was done at the Naval Support Activity Station Hospital, Da Nang, Republic of Vietnam. Dr. Fletcher is now with the Department of Thoracic and Cardiovascular Surgery, US Naval Hospital, National Naval Medical Center, Bethesda, Md. Dr. Butler is presently with the Department of Medicine, Johns Hopkins University, Baltimore. Dr. Kopriva is presently with the Department of; Anesthesia, University of Colorado Medical Center, Denver. Dr. Ratliff is now with the Department of Surgery, University of Mississippi Medical Center, Jackson, Miss.

Arch Intern Med. 1972;129(4):617-619. doi:10.1001/archinte.1972.00320040093012

Twenty-six patients with acute falciparum malaria were evaluated for subclinical changes in arterial blood gases, vital capacity, and coagulation indexes. Comparison of the mean pulmonary and coagulation values for the study with the data for a group of normal subjects showed no statistical difference. Real differences in mean fibrinogen and platelet levels were observed between sample periods. One patient was seen with an unexplained decreased arterial oxygen tension on admission. One patient with cerebral involvement had changes in his coagulation system compatible with consumptive coagulopathy. Further research into the pathophysiology of the pulmonary and cerebral complications of malaria is needed.