Twenty-six patients with acute falciparum malaria were evaluated for subclinical changes in arterial blood gases, vital capacity, and coagulation indexes. Comparison of the mean pulmonary and coagulation values for the study with the data for a group of normal subjects showed no statistical difference. Real differences in mean fibrinogen and platelet levels were observed between sample periods. One patient was seen with an unexplained decreased arterial oxygen tension on admission. One patient with cerebral involvement had changes in his coagulation system compatible with consumptive coagulopathy. Further research into the pathophysiology of the pulmonary and cerebral complications of malaria is needed.
Fletcher JR, Butler T, Kopriva CJ, Ratliff JL. Acute Plasmodium falciparum Malaria: Vital Capacity, Blood Gases, and Coagulation. Arch Intern Med. 1972;129(4):617–619. doi:10.1001/archinte.1972.00320040093012
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