Survival analysis based on a nationwide study of patients in Israel with gallbladder cancer revealed a relatively better survival in two subgroups: (1) patients with a localized tumor at operation and (2) patients with papillary adenocarcinoma. Further breakdown demonstrated that these two factors are interrelated, ie, patients with papillary adenocarcinoma have a relatively higher frequency of localized tumors. Consequently, the group of localized papillary adenocarcinoma of the gallbladder had a median survival extending beyond five years after diagnosis as compared with one month for the total group.
Hart J, Modan B. Factors Affecting Survival of Patients With Gallbladder Neoplasms. Arch Intern Med. 1972;129(6):931–934. doi:10.1001/archinte.1972.00320060079009