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July 1972

Bone Pain in Multiple Myeloma: Studies With Radioactive 87mSr

Author Affiliations


From the sections of nuclear medicine (Department of Radiology) and hematology (Department of Medicine), Temple University Medical School, Philadelphia. Dr. Durant is now with the University of Alabama Medical Center, Birmingham.

Arch Intern Med. 1972;130(1):53-58. doi:10.1001/archinte.1972.03650010041008

Five patients with multiple myeloma were studied by serial radioactive strontium 87mSr citrate or carbonate bone scans over a period of one year. Severe and constant pain was associated with abnormalities on the scans; subsequent roentgenograms of these areas invariably showed vertebral collapse or infraction. On the other hand, old vertebral collapse, per se, did not give rise to bone pain. It is concluded that the cause of the bone pain in myeloma is infraction. Local treatment of such bones with radiation may prevent vertebral collapse and pathologic fracture.