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July 1972

Effect of Hydration and Furosemide Given Intravenously on Proteinuria

Author Affiliations


From the Department of Renal Disease, Cook County Hospital, the Hektoen Institute for Medical Research and the Chicago Medical School-University of Health Sciences, Chicago.

Arch Intern Med. 1972;130(1):90-92. doi:10.1001/archinte.1972.03650010078014

In an attempt to standardize conditions for quantitating proteinuria, we examined the effect of water loading and intravenous administration of furosemide on protein excretion in man. Urine volume, protein excretion, and creatinine clearance increased in both studies, and there was significant correlation between percentage changes in protein excretion and creatinine clearance. We recommend that protein excretion rate should be determined during short periods under standard conditions of posture, hydration, and ideally, without interference by drugs.

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