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July 1972

Hemolysis Due to Anti-A and Anti-B in Factor VIII Preparations

Author Affiliations


From the Division of Pediatrics, Cook County Hospital; the Hektoen Institute for Medical Research; and the Abraham Lincoln School of Medicine of the University of Illinois College of Medicine, Chicago.

Arch Intern Med. 1972;130(1):101-103. doi:10.1001/archinte.1972.03650010087016

In four patients with hemophilia, or von Willebrand's disease, intensive infusion therapy with lyophilized plasma, cryoprecipitate, (Courtland Laboratories), a commercial preparation of fibrinogen and antihemophilic globulin (Fibro-AHF), or antihemophilic globulin (Hemofil) produced hemolysis. The recipients were of blood group A or AB. These materials contained the naturally occurring isoantibodies to A and B erythrocyte antigens. Hemolysis was noted only with intensive replacement therapy. Type-specific cryoprecipitate should be given when prolonged infusion therapy is required following surgical procedures.

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