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September 1972

Intravenously Administered Isoproterenol Sulfate Dose-Response Curves in Man

Author Affiliations


From the Medical Research Council Pharmacology Research Group, Royal Postgraduate Medical School, London. Drs. Conolly and Briant are currently Wellcome Scholars at Vanderbilt University, Nashville, Tenn. Dr. Fenyvasi is currently at Semmelweiss University Medical School, Budapest.

Arch Intern Med. 1972;130(3):361-364. doi:10.1001/archinte.1972.03650030041010

Dose response curves have been constructed for the chronotropic effects of small, rapid intravenous injections of isoproterenol sulfate. In 28 studies performed on 16 normal adults, significant intersubject differences in "receptor sensitivity" were found. In one subject studied on four occasions the dose responses were highly consistent. No adverse effects were encountered. The significance of these findings is discussed in relation to claims of abnormal "receptor sensitivity" in patients with asthma and the hyperkinetic heart syndrome.