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October 1972

Hepatic Synthesis of Bile Acids: Biochemical Steps and Mechanisms of Rate Control

Author Affiliations

New York

From the Department of Lipid Research, the Public Health Research Institute of the City of New York, Inc, and the Bureau of Laboratories, New York City Department of Health.

Arch Intern Med. 1972;130(4):478-487. doi:10.1001/archinte.1972.03650040016003

Bile acid synthesis in the liver is controlled by a negative feedback mechanism: hepatic bile acid synthesis varies inversely with the hepatic bile acid flux. Two regulatory enzymes appear to be involved in this process, cholesterol 7α-hydroxylase and hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. It seems likely that the activity of these enzymes varies in response to changes in the magnitude, circulation rate, and composition of the bile acid pool.