Acquired type 3 hyperlipoproteinemia was observed in two patients with systemic lupus erythematosus. In one, the abnormality disappeared after treatment with adrenocortical steroids for seven months. Transient type 3 hyperlipoproteinemia was also observed in a patient with diabetic ketoacidosis. None of the patients had palmar xanthomata. Type 3 hyperlipoproteinemia was not found among ten family members of these three patients, supporting the concept that these patients represent cases of acquired, rather than inherited, type 3 hyperlipoproteinemia. Postheparin lipase activity (PHLA) was decreased in the two patients with systemic lupus erythematosus. In one, PHLA became normal after adrenocortical steroid treatment concomitantly with the disappearance of the type 3 hyperlipoproteinemia. This finding raises the possibility that PHLA deficiency may have played a role in the development of the type 3 hyperlipoproteinemic pattern.
Stern MP, Kolterman OG, McDevitt H, Reaven GM. Acquired Type 3 Hyperlipoproteinemia: Report of Three Cases Associated With Systemic Lupus Erythematosus and Diabetic Ketoacidosis. Arch Intern Med. 1972;130(6):817–821. doi:10.1001/archinte.1972.03650060013003
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