An 11-year study of 33 patients with lipoid nephrosis treated with a low-dosage prednisolone regime is presented. At the final evaluation 19 patients were in complete remission, 3 in incomplete remission, and 8 had not responded. There were two renal deaths and one nonrenal death. Cyclophosphamide therapy produced a complete remission in four of six patients who did not respond to steroid therapy. Progression of lipoid nephrosis into renal insufficiency was observed in four patients.