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Article
December 1972

Leukocyte Alkaline Phosphatase: Fluctuations With Disease Status in Chronic Granulocytic Leukemia

Author Affiliations

Jamaica and Brooklyn, NY; Brooklyn, NY

From the divisions of hematology, Queens Hospital Center, Affiliation of the Long Island Jewish-Hillside Medical Center and the Coney Island Hospital Affiliated with the Maimonides Medical Center; and the Department of Medicine of the State University of New York, Downstate Medical Center, Brooklyn.

Arch Intern Med. 1972;130(6):892-894. doi:10.1001/archinte.1972.03650060082014
Abstract

Leukocyte alkaline phosphatase activity was determined in 38 patients with chronic granulocytic leukemia. One quarter of the patients who achieved remission had normal leukocyte alkaline phosphatase activity. Three patients in the blastic phase of the disease and three patients who were inadvertently rendered aplastic by chemotherapy had marked increases in enzyme level. These observations suggest that the potential for the production of this enzyme in some patients with chronic granulocytic leukemia is not permanently lost. The source of this increase in leukocyte alkaline phosphatase activity is unknown.

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