The agent in rheumatoid arthritis (RA) synovial tissue has been transmitted from individual patients to normal mice and rats by injection or ingestion. There was a variation in degree of the severity of the characteristic acute lesions in mice induced by the tissue of each individual patient. Similar characteristic lesions were induced in the same manner from RA-affected mouse and rat tissues. Neither injection nor ingestion of normal tissues induced lesions.
Warren SL, Marmor L, Liebes DM, Rosenblatt HM. An Active Agent From Rheumatoid Arthritis Synovial Tissue: Transmission by Injection or Ingestion in Mice and Rats. Arch Intern Med. 1972;130(6):899–903. doi:10.1001/archinte.1972.03650060089016
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