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December 1972

Molecular Aspects of Sickle Cell Hemoglobin: Clinical Applications.

Author Affiliations

Rochester, Minn

Arch Intern Med. 1972;130(6):972-973. doi:10.1001/archinte.1972.03650060156035

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Since sickle cell disease is the classic example of "molecular disease," it is appropriate that a new treatise on this disorder be founded strongly on concepts of molecular malfunction and new therapy should be directed at modification of molecular interactions. The first chapter of this book does, indeed, review the molecular aberrations of sickle hemoglobin. The ingenious hypothesis of molecular stacking of hemoglobin S is ably reviewed by Murayama, who originally proposed this concept. "Molecular aspects" also are reviewed in the beginning of the second chapter. Seventy pages (not quite half of the book) are then devoted to microscopy. The descriptions of the sequence of erythrocyte deformation are interesting, and the illustrations are beautiful. (One wonders, however, whether allocation of 27 full pages to reproductions of scanning electron micrographs of red cells is not somewhat excessive.) The remainder of the volume presents in considerable detail the author's rationale and methods

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