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December 1972

Pathology of Sickle Cell Disease.

Author Affiliations

Rochester, Minn

Arch Intern Med. 1972;130(6):973. doi:10.1001/archinte.1972.03650060157036

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In the preface, the author seems to imply that the information presented in this book was derived from a study of 422 cases of sickle cell disease. One's expectation is that this monograph will provide a careful analysis of pathologic changes observed in this substantial source. This expectation is not realized. Indeed, one looks very hard to find any data whatever derived from the author's study of sickle cell disease. In fact, what is presented is a broad review of sickle cell disease, thalassemia, glucose-6-phosphate dehydrogenase deficiency, and related topics. Much of the literature reviewed is obsolete, irrelevant, and does not merit a place in a modern textbook except, perhaps, in the chapter on history.

The first two chapters are almost entirely historical, although the second (entitled "The Hemoglobin Molecule") does have an antiquated diagram of the α and β chains. The subject matter is not well organized by chapter.

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