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March 1973

Uremia: Progress and Pathophysiology on Treatment.

Author Affiliations

Nashville, Tenn

Arch Intern Med. 1973;131(3):468. doi:10.1001/archinte.1973.00320090158025

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In 92 pages of text and 30 illustrations, backed by 297 references and their own extensive experience and contributions in this field, the authors have updated a decade of literature and concepts on pathophysiology and treatment of uremia in a most competent manner.

The initial discussion reviews renal functional behavior when renal mass is reduced, citing the "intact nephron hypothesis" of Bricker as a conceptual summary of the myriad, highly appropriate functional adjustments that support homeostasis. Next, in a disappointing section on the quest for the toxin of uremia, the authors first imply a need for an experimental test system involving uremic signs and symptoms and their response to dialysis. Then they make a categorical and unsubstantiated affirmation that precise psychological and behavioral testing methods exist and are of value in man rather than in animals. Finally they proceed to recount a series of findings in organs, tissues, cells, and

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