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March 1973

Clinical Hypersensitivity Disorders.

Arch Intern Med. 1973;131(3):473. doi:10.1001/archinte.1973.00320090163037

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This volume is part of the American Lecture series in Living Chemistry. It is written for undergraduates and postgraduates in medical and paramedical fields.

Pathogenetic mechanisms resulting from experimental observations are applied to the manifestations of clinical hypersensitivity and classified into two principal categories depending on whether humoral or cellular mechanisms predominate. The author does this in a clear and concise fashion, marshalling all the present knowledge to sustain his position and citing references that are not in conformity with it. Unfortunately, our inability to identify many of the specific factors in syndromes alleged to be of immunological origin continues to exist.

The bibliography is extensive, comprising 28 pages and a total of 424 references; some date back to the original observations of the last century, but many are of 1970 vintage. There are excellent discussions of the events leading to or responsible for each of the clinical syndromes, including

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