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May 1973

Paget Disease of Bone: Long-Term Treatment With Salmon Calcitonin

Author Affiliations

Galveston, Tex

From the Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Texas Medical Branch, Galveston.

Arch Intern Med. 1973;131(5):722-724. doi:10.1001/archinte.1973.00320110106016

An elderly patient with painful Paget disease was treated for a period of one year with intramuscular injections of 100 Medical Research Council units of synthetic salmon calcitonin. During this period, she experienced marked improvement in her bone pain. The serum alkaline phosphatase level dropped from a pretreatment level of 7.8 to 1.4 Sigma units and the urinary hydroxyproline level fell from a pretreatment level of 69.3 to 21.3 mg/day. The lack of significant adverse reactions and the suppressive effects of calcitonin on the subjective and objective manifestations of Paget disease make this agent an important therapeutic advance.