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June 1973

Excretion of Phosphate and Calcium: Physiology of Their Renal Handling and Relation to Clinical Medicine

Author Affiliations

Los Angeles

From the Renal and Hypertension Service, the Medical Research Institute, and the Department of Medicine, Cedars-Sinai Medical Center, Veterans Administration Wadsworth Hospital Center; and University of California at Los Angeles School of Medicine.

Arch Intern Med. 1973;131(6):828-859. doi:10.1001/archinte.1973.00320120068006

This report reviews the various factors involved in the control of the renal excretion of phosphate and calcium. We discuss the effects of changes in glomerular filtration rate, renal vasodilatation, extracellular fluid volume expansion, diuretics, state of body stores of phosphate, acid-base status, diet, and various hormones. This physiological knowledge forms a background for the discussion of the abnormalities in the excretion of phosphate and calcium observed in various disease states.

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