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June 1973

Recent Advances in the Physiology and Pathophysiology of Potassium Excretion

Author Affiliations

Los Angeles

From the Department of Medicine, UCLA School of Medicine, Los Angeles.

Arch Intern Med. 1973;131(6):885-897. doi:10.1001/archinte.1973.00320120125009

Recent micropuncture data have confirmed that the distal convoluted tubule plays a leading role in potassium secretion. Earlier concepts of a 1:1 exchange between sodium and potassium or hydrogen ion must be modified in light of recent findings. Plasma potassium levels may change the rate of renin secretion, and total body potassium depletion may alter the ability to concentrate and acidify the urine.