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June 1973

Immunopathology 6.

Arch Intern Med. 1973;131(6):941. doi:10.1001/archinte.1973.00320120181017

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This is the sixth in a series of symposia on immunopathology. These meetings have earned a reputation for gathering the most important contributions in basic immunopathology. There has always been strong emphasis on detailing pathogenetic mechanisms, and this volume follows this tradition.

There are interesting sections on cellular cooperation involving thymus and bone marrow cells, immunological deficiency, and the chemistry and functions of the immunoglobulin classes with particular emphasis on IgE and abnormalities of α-chain metabolism.

There is an authoritative section on antibody-mediated inflammatory processes, with interesting presentations on the chemistry of human anaphylatoxin, specific inhibition of histamine and slow-reacting substance (which are tissue mediators of immediate type hypersensitivity), and a detailed analysis of the precursors of the kinin-forming system with some observations on their activation.

A paper on renal grafts clearly describes the role of humoral antibody in hyperacute rejection. This section was followed by presentations on cell-mediated mechanisms

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