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July 1973

Primary Hyperparathyroidism Presenting as a Giant Cell Tumor of the Maxilla

Author Affiliations

Oklahoma City and Durham, NC

From the departments of medicine (Drs. Males, Mask, and Townsend), and otorhinolaryngology (Dr. Snow), University of Oklahoma Medical Center, Oklahoma City, and the Department of Medicine, Division of Endocrinology (Drs. Howard and McPherson), Duke University Medical Center, Durham, NC. Dr. Males is now with the 97th General Hospital, Frankfurt, Germany.

Arch Intern Med. 1973;132(1):107-111. doi:10.1001/archinte.1973.03650070093015

Two cases of primary hyperparathyroidism presented as giant cell tumors of the maxillary sinus. The presence of hypercalcemia and multiple skeletal lesions appear to be the major distinguishing points among lesions with very similar histologic appearances: fibrous dysplasia, reparative giant cell granuloma, true giant cell tumor, and brown tumor of hyperparathyroidism. The clinical pattern in these two cases were similar, with the rather rapid development of symptoms and postoperative, transient tetany, which occurred during the period when bone remineralization was underway. The maxillary tumor became calcified in one instance, and responded dramatically to teletherapy with radioactive cobalt (60Co) in the other.