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September 1973

Lung Carcinoma Associated With Production of Three Placental Proteins: Ectopic Human Chorionic Gonadotropin, Human Chorionic Somatomammotropin, and Placental Alkaline Phosphatase

Author Affiliations

Washington, DC; San Francisco; Washington, DC; Bethesda, Md; Boston

From the Department of Medicine, Walter Reed General Hospital (Dr. Charles), and Division of Medicine, Walter Reed Army Institute of Research (Dr. Schaaf), Washington, DC; Department of Medicine, Letterman General Hospital, San Francisco (Dr. Claypool); Clinical Endocrinology Branch, National Institute of Arthritis and Metabolic Diseases, Bethesda, Md (Dr. Rosen); and Thyroid Unit, Massachusetts General Hospital, Boston (Dr. Weintraub). Dr. Charles is now at the Metabolic Research Unit, University of California Medical Center, San Francisco.

Arch Intern Med. 1973;132(3):427-431. doi:10.1001/archinte.1973.03650090097018

Production of human chorionic gonadotropin (HCG), human chorionic somatomammotropin (HCS),1 and the placental isozyme of alkaline phosphatase (PAP) by normal and neoplastic trophoblast has been well documented.2-5 (Previously, HCS has been designated as human placental lactogen [HPL], chorionic growth hormone-prolactin [CGP], purified placental protein [human] [PPP(H)], and placental protein. Because of the site of formation and physiologic effects of this protein hormone, the name HCS has been recommended1 and will be used throughout this report.)

The ectopic production of gonadotropins by nontrophoblastic tumors has also been established.6-9 With a single exception,10 the gonadotropin has invariably behaved like luteinizing hormone (LH) or HCG,11 but until recently, methods have not been readily available to permit unequivocal differentiation of the placental from the pituitary hormone.12,13 Ectopic production of the placental proteins PAP and HCS has also been described14,15 in a variety of nontrophoblastic neoplasms, contrasting

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