A patient had acute myelomonocytic leukemia occurring after a period of pancytopenia associated with the administration of chloramphenicol. Karyotype analysis showed the presence of a large marker chromosome present in all scorable cells. This chromosome is similar to one described in some other myeloproliferative disorders and raises the possibility of such a chromosomal alteration playing a role in the transition to acute leukemia.
Cohen HJ, Huang AT. A Marker Chromosome Abnormality: Occurrence in Chloramphenicol-Associated Acute Leukemia. Arch Intern Med. 1973;132(3):440–443. doi:10.1001/archinte.1973.03650090110021
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