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September 1973

A Marker Chromosome Abnormality: Occurrence in Chloramphenicol-Associated Acute Leukemia

Author Affiliations

Durham, NC

From the Department of Medicine, Duke University Medical Center, and the Durham Veterans Administration Hospital (Dr. Huang), Durham, NC.

Arch Intern Med. 1973;132(3):440-443. doi:10.1001/archinte.1973.03650090110021

A patient had acute myelomonocytic leukemia occurring after a period of pancytopenia associated with the administration of chloramphenicol. Karyotype analysis showed the presence of a large marker chromosome present in all scorable cells. This chromosome is similar to one described in some other myeloproliferative disorders and raises the possibility of such a chromosomal alteration playing a role in the transition to acute leukemia.