The problem of renal lesions in association with subacute bacterial endocarditis (SBE) is a frequent clinical situation that was encountered early in the systematic study of this disease.1-7 We report a carefully studied case of SBE due to Streptococcus mitis that was complicated by glomerulonephritis and discuss the causes of glomerular lesions in SBE. The results of direct immunofluorescent stains on fresh renal tissue from our patient led us to believe that such renal lesions are, at least in some instances, a manifestation of an immune complex nephritis. The pattern of fluorescent staining appeared to be a lumpy-bumpy one of the type previously recorded by many investigators in association with glomerular deposition of antigen-antibody complexes.8-12
A 49-year-old Spanish-American man, a former hard-rock miner was admitted in December 1970 to Bataan Memorial Hospital, Albuquerque, NM, for epistaxis and abnormal bone marrow findings. The patient had acute rheumatic
Keslin MH, Messner RP, Williams RC. Glomerulonephritis With Subacute Bacterial Endocarditis: Immunofluorescent Studies. Arch Intern Med. 1973;132(4):578–581. doi:10.1001/archinte.1973.03650100090017
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