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October 1973

Glomerulonephritis With Subacute Bacterial Endocarditis: Immunofluorescent Studies

Author Affiliations

Albuquerque, NM

From the Department of Medicine, Bernalillo County Medical Center, University of New Mexico School of Medicine, Albuquerque.

Arch Intern Med. 1973;132(4):578-581. doi:10.1001/archinte.1973.03650100090017

The problem of renal lesions in association with subacute bacterial endocarditis (SBE) is a frequent clinical situation that was encountered early in the systematic study of this disease.1-7 We report a carefully studied case of SBE due to Streptococcus mitis that was complicated by glomerulonephritis and discuss the causes of glomerular lesions in SBE. The results of direct immunofluorescent stains on fresh renal tissue from our patient led us to believe that such renal lesions are, at least in some instances, a manifestation of an immune complex nephritis. The pattern of fluorescent staining appeared to be a lumpy-bumpy one of the type previously recorded by many investigators in association with glomerular deposition of antigen-antibody complexes.8-12

Patient Summary  A 49-year-old Spanish-American man, a former hard-rock miner was admitted in December 1970 to Bataan Memorial Hospital, Albuquerque, NM, for epistaxis and abnormal bone marrow findings. The patient had acute rheumatic

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