Nephrotic syndrome in association with Hodgkin disease may be caused by the deposition of immune complexes within the kidney. A patient with Hodgkin disease is reported in whom the nephrotic syndrome developed. Immunoglobulin deposits and electron-dense accumulations were demonstrated in the glomerular basement membranes. A clinical remission was achieved with therapy that was specifically directed at the Hodgkin disease. The hypothesis is proposed that Hodgkin disease tumor-specific antigens may compose a portion of the deposited immune complexes.
Lokich JJ, Galvanek EG, Moloney WC. Nephrosis of Hodgkin Disease: An Immune Complex-Induced Lesion. Arch Intern Med. 1973;132(4):597–600. doi:10.1001/archinte.1973.03650100105020
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