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November 1973

Clinical and Metabolic Characteristics: Effects on Mortality in Coronary Disease

Author Affiliations

Columbus, Ohio

From the Department of Medicine, Division of Endocrinology and Metabolism, Ohio State University Hospitals, Columbus. Dr. Reynertson is now at the Department of Medicine, University of Alabama, Birmingham.

Arch Intern Med. 1973;132(5):649-653. doi:10.1001/archinte.1973.03650110011003

A prospective study of 137 patients aged 50 years or less with coronary heart disease was begun in 1965. Twenty-seven patients have died during the course of the study, all from cardiovascular causes. Clinical and metabolic characteristics on entry into the study have been related to subsequent mortality. The findings suggest that an elevated base line serum cholesterol level is associated with a significantly increased mortality. Myocardial infarction rather than angina pectoris at entry into the study, as well as duration of symptomatic coronary disease prior to entry, were characteristics adversely affecting survival. Serum triglyceride levels, glucose tolerance, immunoreactive insulin responses to orally ingested glucose, and body weight did not appear to affect survival in persons with established coronary heart disease.

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