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November 1973

Diagnosis of Deep Infection With Candida: A Study of Candida Precipitins

Author Affiliations

Palo Alto, Calif; Stanford, Calif

From the Division of Allergy, Immunology and Infectious Diseases. Palo Alto Medical Research Foundation, Palo Alto, Calif, and the Department of Medicine, Division of Infectious Diseases, Stanford University School of Medicine, Stanford, Calif.

Arch Intern Med. 1973;132(5):699-702. doi:10.1001/archinte.1973.03650110049010

The potential diagnostic value of the Candida precipitin test was evaluated in the population of 133 hospitalized patients suspected of having deep infection with Candida organisms. Precipitins were found in 26 patients and in 24 (92%) of them deep Candida infection was documented. Multiple surgery and leukemia were the most frequent underlying conditions among the 26 patients with deep infection with Candida. There were two (2%) false-negative reactions among the 107 patients in whom precipitins were not found. Candida precipitins were not found in 87 control subjects or individuals with other fungal diseases. Fifteen (57%) of the 26 patients with deep Candida infection received antifungal therapy and survived. Nine (81%) of the eleven patients who died had not received adequate therapy. The precipitin test may be useful in the early diagnosis of deep infection with Candida.