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November 1973

Candida Endophthalmitis: A Complication of Candidemia

Author Affiliations


From the departments of medicine and ophthalmology, Harvard Medical School; the Infectious Disease Unit, Department of Medicine, Massachusetts General Hospital; and the Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston. Dr. Weinstein is now at the University of Pennsylvania, Philadelphia.

Arch Intern Med. 1973;132(5):749-752. doi:10.1001/archinte.1973.03650110083018

With newer forms of therapy, such as the use of cytotoxic agents and immunosuppression, and with the placement for extended periods of time of long intravenous lines utilized for hyperalimentation and antibiotic administration, the incidence of isolations of Candida species from blood cultures has increased. Previous reports have emphasized the local and systemic complications of intravenous lines,1-4 the seriousness of candidemia,5 and the relation of candidemia to antibiotic therapy.6,7 Recently, six patients with candidemia and Candida endophthalmitis have been described.8 All six had received antibiotics systemically and had indwelling intravenous catheters for prolonged periods of time. We describe two additional patients who had a similar complication of the use of systemic antibiotics and intravenous catheters. We emphasize the importance of prompt detection of the lesions and the early institution of therapy with amphotericin B. Both patients demonstrated marked improvement in conjunction with systemic antifungal therapy.