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November 1973

Carbenoxolone Sodium.

Author Affiliations



Edited by J.H. Baron and F.M. Sullivan. Price, $11.75. Pp 171. Appleton-Century-Crofts, 440 Park Ave S, New York 10016, 1972.

Arch Intern Med. 1973;132(5):777. doi:10.1001/archinte.1973.03650110109035

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This is a series of papers presented at a special group meeting on carbenoxolone sodium held at the World Congress of Gastroenterology in 1970.

Carbenoxolone is a derivative of glycyrrhizinic acid. The latter is found in licorice, which has been observed to be helpful in treatment of gastric ulcer. Some feel that the active principle in licorice is carbenoxolone; others have removed the precursor of carbenoxolone from licorice and are just as adamant that the residue is as effective. There seem to be few cross references in the published papers from either camp. This is disquieting and makes an entirely objective review of the subject rather difficult.

There is no question that carbenoxolone is an interesting compound. It has anti-inflammatory properties, and it causes sodium retention. If cardiologists are concerned about the long-term complications of ingesting cream during ulcer therapy, one can only wonder about their response when they discover

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