Sixteen, randomly-selected, physically fit, young men, undergoing a vigorous, four-month, underwater demolition-team training program, showed marked alterations in their serum uric acid concentrations that could not be accounted for by simultaneous alterations in their urinary indices of either uric acid production or excretion. Significant elevations in subjects' serum uric acid levels corresponded to periods of mental alertness and preparedness on their parts to meet with new challenges in training. The elevations seen in subjects' serum uric acid concentrations at these times may have been due to changes in their blood or plasma volume, secondary to a release of adrenal catecholamines.
Zir LM, McHugh WB, Rahe RH, Arthur RJ, Rubin RT. Renal Excretion of Uric Acid: Alterations During Stressful Underwater Demolition-Team Training. Arch Intern Med. 1973;132(6):808–812. doi:10.1001/archinte.1973.03650120020004
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: