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December 1973

Renal Excretion of Uric Acid: Alterations During Stressful Underwater Demolition-Team Training

Author Affiliations

San Diego, Calif; Torrance, Calif

From the Biochemical Correlates Division, Medical Neuropsychiatric Research Unit, San Diego, Calif (Drs. Zir, McHugh, Rahe, and Arthur) and the Department of Psychiatry, University of California at Los Angeles, Harbor General Hospital, Torrance (Dr. Rubin).

Arch Intern Med. 1973;132(6):808-812. doi:10.1001/archinte.1973.03650120020004

Sixteen, randomly-selected, physically fit, young men, undergoing a vigorous, four-month, underwater demolition-team training program, showed marked alterations in their serum uric acid concentrations that could not be accounted for by simultaneous alterations in their urinary indices of either uric acid production or excretion. Significant elevations in subjects' serum uric acid levels corresponded to periods of mental alertness and preparedness on their parts to meet with new challenges in training. The elevations seen in subjects' serum uric acid concentrations at these times may have been due to changes in their blood or plasma volume, secondary to a release of adrenal catecholamines.