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December 1973

Glucagon and Isoproterenol in Reversing Propranolol Toxicity

Author Affiliations

Winston-Salem, NC

From the Department of Physiology, Bowman Gray School of Medicine, Winston-Salem, NC. Dr. Malindzak is now at the Environmental Protection Agency, University of North Carolina, Chapel Hill, and Dr. Kosinski is at the Department of Medicine, Columbia University Medical Center, New York.

Arch Intern Med. 1973;132(6):840-843. doi:10.1001/archinte.1973.03650120048009

The hemodynamic properties of glucagon hydrochloride and isoproterenol hydrochloride were compared in anesthetized mongrel dogs before and after complete β-adrenergic blockade with propranolol hydrochloride. Before propranolol blockade, glucagon and isoproterenol enhanced myocardial performance, although the action of glucagon persisted longer than that of isoproterenol. Following propranolol blockade, glucagon enhanced myocardial contractility and heart rate to a greater extent than isoproterenol. Glucagon is clinically superior in reversing the toxic effects of propranolol.

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