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December 1973

Basic Immunogenetics.

Author Affiliations

San Francisco


H. Hugh Fudenberg, J.R.L. Pink, Daniel P. Stities, and AnChuan Wang. Price, $9.50. Pp 250. Oxford University Press, 200 Madison Ave, New York 10016, 1972.

Arch Intern Med. 1973;132(6):911-912. doi:10.1001/archinte.1973.03650120109023

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The beauty of this book is in its manner of covering a topic at a broad clinical level, then pursuing it down to its macromolecular basis. The immunologic discussion is written with the same clarity and organization as the phenotypic description.

An inexperienced immunogeneticist should first read the appendix on blood-group terminology. The preface acknowledges the penetrance of the writers' research interest in choice of subject matter. This influence is apparent by the book's hematologic orientation. The primary topics include: "Immunologic Structure and Evolution," "The Genetics of Immunoglobulin Molecules," "Antibody Variability," "Cells, Genes and the Immune Response," and "Immunogenetics of Human Blood Groups." The latter topic is possibly the best written with particularly clear biochemical and immunological explanations of how the groups were discovered and applied to clinical medicine. A wholesome aspect of this book is the authors' scrupulous care in giving credit to individual major investigators who accounted for

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