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February 1974

Fat Embolization Prophylaxis: Use of Hypertonic Glucose

Author Affiliations

Salt Lake City, Utah

From the University of Utah Medical School and Cottonwood Hospital, Salt Lake City.

Arch Intern Med. 1974;133(2):288-291. doi:10.1001/archinte.1974.00320140126014

Eighty-nine patients with multiple system injuries, including fractures of the pelvis, femur, or tibia, were observed. Serum determinations of cholesterol, free fatty acids, and total lipids showed a decrease of each of these substances in the blood, following institution of hypertonic glucose therapy. The possible mechanisms of actions on the triglyceride level, liver function, and secretion of norepinephrine and cortisone were determined. In the series of patients with multiple system injuries, the prophylactic treatment with intravenous administration of hypertonic glucose has eliminated fat embolization as a complication.

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