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Volume I of this monumental undertaking dealt exclusively with the hormone progesterone. It is a mine of information for the pharmacologist and physiologist. The section on human studies dealt primarily with the metabolism of progesterone and its effect on the uterovaginal tract.
This second volume deals with derivatives of and synthetic substitutes for progesterone and summarizes most of what is known of the pharmacology of these compounds in experimental animals and man. Most of the text is straightforward animal pharmacology; it is comprehensive, yet condensed into a most usable form. There is a chapter on the therapeutic application of progestational drugs that is of interest to obstetricians and gynecologists.
The section of greatest interest to clinicians is the final one on oral contraceptives. Tragically, this is by far the weakest section in the two volumes. The authors still concern themselves with quibbles about priority that were unworthy of serious attention
Goldzieher JW. Pharmacology of the Endocrine System and Related Drugs: Progesterone, Progestational Drugs & Antifertility Agents, vol 2. Arch Intern Med. 1974;133(2):328. doi:10.1001/archinte.1974.00320140166045
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