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March 1974

Urate Metabolism in Sarcoidosis

Author Affiliations

Washington, DC; Philadelphia; Washington, DC

From the Department of Medicine, Veterans Administration Hospital (Drs. Goldstein and Becker and Mr. Moore), and George Washington University Medical Center, Washington, DC, (Drs. Goldstein and Becker), and the Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia (Dr. Israel).

Arch Intern Med. 1974;133(3):379-381. doi:10.1001/archinte.1974.00320150053005

For years, there has been considerable controversy about the presence of hyperuricemia and of clinical gout in sarcoidosis. This study was performed in order to clarify these issues. Measurement of the renal excretion of urate in 12 sarcoidosis patients receiving diets with normal purine and reduced purine contents and fasting for a short term disclosed no marked abnormalities when compared with six control subjects. Serum urate levels were also measured in 124 other patients with sarcoidosis. Mean values were not markedly different from those found in 39 healthy persons. Minimal elevations occurred in four of 35 men and in seven of 89 women. The elevations appeared to be unrelated to articular manifestations of sarcoidosis. The triad of sarcoidosis, psoriasis, and gout was not observed. Sarcoidosis is rarely associated with major disturbances of urate metabolism.

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