[Skip to Navigation]
March 1974

Cure of Aspergillus ustus Endocarditis on: a Prosthetic Valve

Author Affiliations


From the Department of Medicine, the Medical College of Pennsylvania, and the Philadelphia Veterans Administration Hospital, Medical College of Pennsylvania Division, Philadelphia.

Arch Intern Med. 1974;133(3):486-490. doi:10.1001/archinte.1974.00320150160023

The almost uniformly fatal outcome of Aspergillus endocarditis, most of which has occurred on prosthetic cardiac valves, has been well documented.1,2 The difficulty in the diagnosis of this type of infection, the problems of therapy of prosthetic valve endocarditis, and the relative ineffectiveness of antifungal chemotherapeutic agents account for the high mortality.

We describe a patient with Aspergillus endocarditis on a prosthetic valve who was cured with a combination of surgery, amphotericin B therapy, and long-term therapy with flucytosine. (This patient was included in a previous report of two patients with Aspergillus endocarditis,3 but the details and results of therapy were not included in that report.) A review of the literature on Aspergillus endocarditis is also included.

Patient Summary 

Patient 1.  —A 50-year-old black man was first admitted to the Philadelphia Veterans Administration Hospital in February 1963 because of increasing symptoms of heart failure. He had had rheumatic

Add or change institution