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April 1974

The Sickle Cell DiseasesClinical Manifestations Including the "Sickle Crisis"

Author Affiliations

Glasgow, FGA, Accra, Ghana

From the Department of Medicine and Therapeutics, Korle Bu Teaching Hospital, Korle Bu, Ghana.

Arch Intern Med. 1974;133(4):611-619. doi:10.1001/archinte.1974.00320160105009

Working definitions of "sickle cell disease," "sickle-cell trait," and "the sickle crisis" are given. The pathogenesis of the crisis is explained and the complications of the disease are presented in a quantitative manner. The need to look at the patient as a whole and to assess the natural history of the disease against the background of an often prevalent social and environmental pathologic condition is stressed. A call for effective public health measures, including raising of living standards and providing comprehensive health care facilities for sickle cell disease patients is made.