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April 1974

The Sickle Cell Diseases: Clinical Manifestations Including the "Sickle Crisis"

Author Affiliations

Glasgow, FGA, Accra, Ghana

From the Department of Medicine and Therapeutics, Korle Bu Teaching Hospital, Korle Bu, Ghana.

Arch Intern Med. 1974;133(4):611-619. doi:10.1001/archinte.1974.00320160105009

Working definitions of "sickle cell disease," "sickle-cell trait," and "the sickle crisis" are given. The pathogenesis of the crisis is explained and the complications of the disease are presented in a quantitative manner. The need to look at the patient as a whole and to assess the natural history of the disease against the background of an often prevalent social and environmental pathologic condition is stressed. A call for effective public health measures, including raising of living standards and providing comprehensive health care facilities for sickle cell disease patients is made.

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