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May 1974

Fetal Pharmacology.

Author Affiliations

Durham, NC

Arch Intern Med. 1974;133(5):876. doi:10.1001/archinte.1974.00320170152032

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.


It is estimated that about 2% to 3% of all congenital malformations in man can be attributed to drugs or other chemicals in the environment. Cancers also may result from chemical exposures prenatally, since diethylstilbestrol therapy in pregnant women has been linked recently to the development of vaginal cancer in their daughters. This book stems from a symposium on fetal pharmacology held in Stockholm in December 1971. It reviews in depth the current evidence implicating drugs in teratogenesis.

In this volume, the fetus is looked on as a potential patient. Basic pharmacologic principles have been applied, and opportunities as well as risks are considered. This approach has been stimulated by recent advances in clinical pharmacology and in the increased technology of fetal monitoring, chemical microanalyses of drugs, and improved prenatal diagnostic methods and techniques.

The comprehensive text of 487 pages includes information on drug distribution, drugs and autonomic function, drug

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