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July 1974

Evaluation of Drug Interactions, ed 1.

Author Affiliations

Kansas City, Kan

Arch Intern Med. 1974;134(1):185-186. doi:10.1001/archinte.1974.00320190187050

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The uncritical publication of long lists of drug interactions has led to an illness in physicians known as the "drug interaction anxiety syndrome." The most severe form of this syndrome results in "therapeutic paralysis." There is little doubt that drug interactions may have serious clinical consequences; however, the publication of long lists of interactions has aroused overconcern in practicing physicians, even though these tabulations included animal data, case reports, and clinical impressions of unproved therapeutic importance. Evaluation of Drug Interactions attempts, by means of panels of physicians, pharmacists, and pharmacologists, to evaluate the literature critically and indicate the clinical importance of reported drug interactions. The book was assembled by 26 scientific review and five practitioner panels. This book is an improvement over available publications on this subject, but it still fails in some regards.

The initial section contains specific reviews on 104 pairs of drugs and includes pharmacological effect and

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