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August 1974

The Spectrum of Diseases Associated With Thymoma: Coincidence or Syndrome?

Author Affiliations

Rochester, Minn

From the Mayo Clinic and Mayo Foundation, Rochester, Minn (Dr. Silverstein), and the departments of medicine and pathology, University of Sherbrooke, Sherbrooke, Quebec (Drs. Enriquez and Pépin). Dr. Souadjian is now at the University of California (Irvine), Orange County Medical Center, Orange, Calif.

Arch Intern Med. 1974;134(2):374-379. doi:10.1001/archinte.1974.00320200184029

Among 598 patients with thymoma (452 found in the literature and 146 from the Mayo Clinic), 422 (71%) suffered from 493 other diseases suspected of being associated with thymoma; 423 of these cases involved disorders of immunity. In contrast, there were only 21 patients (12%) each with one case of these other diseases among 177 Mayo Clinic patients with parathyroid adenoma; 19 of these involved immunity disorders. The total of 423 cases of diseases related to disorders of immunity included, among others, myasthenia gravis (44%), cytopenias (21%), cancer (17%), hypogammaglobulinemia (6%), polymyositis (5%), and systemic lupus erythematosus (2%). These findings merit consideration of thymoma together with certain diseases as a syndrome rather than as a spectrum of coincidental diseases.

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